Delivery Plan is for "Under-Investigated" Chronic Fatigue Syndromes (Erroneously being labeled as "ME/CFS") | NOT for Myalgic Encephalomyelitis (also known as "Enteroviral Encephalomyelitis") which has no plan - 4 News, Ch4

Featuring Nick Benton, John Benton, Dr. Binita Kane and Sir Sajid Javid

Chronic Fatigue Syndromes - These ain't M.E. Patients

"Under-Investigated" Chronic Fatigue Syndromes and Their Criterias

IOM's Systemic Exertion Intolerance Disease (2015) Algorithm - a new name for "Chronic Fatigue Syndrome"

https://me-pedia.org/wiki/Systemic_Exertion_Intolerance_Disease

Myalgic Encephalomyelitis (also known as "Enteroviral Encephalomyelitis") is EXCLUDED under "Consider Another Diagnosis")

Canadian Consensus Criteria (2003)

https://me-pedia.org/wiki/Canadian_Consensus_Criteria

The CCC addresses the exclusion of conditions like "Enteroviral Encephalomyelitis" under its "overall requirement to rule out other explanatory medical conditions".

Although such a specific illness isn’t listed by name, any active infection or neurological disorder - including "Enteroviral encephalomyelitis" - must be "excluded" through appropriate diagnostic workup before the CCC for "Chronic Fatigue Syndromes" can be applied.

Myalgic Encephalomyelitis (also known as "Enteroviral Encephalomyelitis")

https://me-pedia.org/wiki/Myalgic_encephalomyelitis

"Epidemic" Myalgic Encephalomyelitis (also known as "Enteroviral Encephalomyelitis")

https://me-pedia.org/wiki/Epidemic_myalgic_encephalomyelitis

Enterovirus

https://me-pedia.org/wiki/Enterovirus

Enterovirus PCR

https://www.leedsth.nhs.uk/services/pathology/tests/enterovirus-pcr/

Viral Faecal samples for investigation other than gastroenteritis

https://www.leedsth.nhs.uk/services/pathology/tests/viral-faecal-samples-for-investigation-other-than-gastroenteritis/

Enterovirus Protein (VP1) Immunoperoxidase Staining assay measures the presence of enterovirus protein in stomach tissue, or other tissue types.

https://www.evmedresearch.com/store/p1/Enterovirus_Protein_%28VP1%29_Immunoperoxidase_Staining.html

1934 Los Angeles County General Hospital "Atypical Poliomyelitis" (precursor name to "Myalgic Encephalomyelitis") Outbreak

https://me-pedia.org/wiki/1934_Los_Angeles_atypical_polio_outbreak

1955 Royal Free Hospital Outbreak of Myalgic Encephalomyelitis (also known as "Enteroviral Encephalomyelitis")

https://me-pedia.org/wiki/1955_Royal_Free_Hospital_outbreak

"Acute Onset" Myalgic Encephalomyelitis Definitions and Criterias

Nightingale Research Foundation Definition (Clinical Definition) (2016) - "Enteroviral Encephalomyelitis"

https://me-pedia.org/wiki/Nightingale_Research_Foundation_definition

MRI findings of "Enteroviral Encephalomyelitis" (2016)

https://www.sciencedirect.com/science/article/pii/S0378603X16300638

Muscle Fatigability followed by Motor Weakness

https://me-pedia.org/wiki/Muscle_fatigability

Myalgic Encephalomyelitis (ME) or What? An Operational Definition (2018)

https://www.mdpi.com/2075-4418/8/3/64

Myalgic encephalomyelitis—a persistent enteroviral infection? (1990)

https://academic.oup.com/pmj/article-abstract/66/777/526/7061518?redirectedFrom=fulltext

International Consensus Criteria (ICC) (2011) - Closest Symptom-Based Criteria to M.E.

https://me-pedia.org/wiki/International_Consensus_Criteria

Diffusion tensor imaging reveals neuronal microstructural changes in Myalgic Encephalomyelitis patients and none in Fukuda's Chronic Fatigue Syndrome patients (2021)

https://onlinelibrary.wiley.com/doi/10.1111/ejn.15413

Our study demonstrated that DTI parameters are sensitive to microstructural changes in ME ICC and could potentially act as an imaging biomarker of abnormal pathophysiology in M.E.

3.1 Group comparison: CFS Fukuda (Evolved into CCC and IOM's SEID)

We performed a group comparison between 25 CFS Fukuda and 26 HCs for all seven DTI parameters. None of the DTI parameters showed a statistically significant cluster (p < .05) despite relaxing the p-uncorrected voxel threshold to .005.

CFS Fukuda subjects were "excluded" from subsequent analysis.

3.2 Group comparison: ME ICC

We performed voxel-based analysis on FA, AD, MD, RD, λ2 and λ3 images estimated for 18 ME ICC.

Figure 1 shows significant clusters with decreased AD, MD and λ2 in the midbrain and pons in the brainstem in ME patients as well as in the superior longitudinal fasciculus (SLF) region for MO.

Figure 2 shows significant clusters with increased λ3 in the dorsal medulla for ME ICC.

The study also shows that strict case definitions are essential in investigation of the pathophysiology of M.E. and CFS patients.