Did you know that Turmeric is an anti-parasitic?

Did you know that Turmeric is an anti-parasitic?

Key Studies on Turmeric/Curcumin as an Antiparasitic Agent

1. Schistosoma mansoni (a parasitic worm)
• A 2017 mouse study found that turmeric significantly reduced S. mansoni worm burden and granuloma size, though it was still less effective than the standard drug praziquantel (PZQ). Combining turmeric with PZQ offered some added histopathological improvements.
• A 2020 study using curcumin-loaded nanoparticles combined with PZQ showed dramatic results—in mice, this regimen reduced worm burden by ~97%, egg counts in liver/intestine by over 95%, and granuloma size by around 70%

2. Broad-spectrum Antiparasitic Review (2018)
• A comprehensive 2018 review evaluated curcumin’s effect across a variety of parasites—from protozoa to helminths—and concluded that curcumin shows high potential as an effective antiparasitic agent, though it emphasized the need for further detailed studies.

3. Besnoitia besnoiti (a protozoan parasite affecting cattle)
• In vitro studies found that curcumin reduced tachyzoite viability (IC₅₀ = 5.93 μM), impaired motility, blocked host-cell invasion, and hindered parasite replication. The study suggests potential for curcumin as a bovine besnoitiosis control strategy.

4. Leishmania major (causes cutaneous leishmaniasis)
• A 2024 study exploring nanoemulsion formulations of curcumin (CUR-NE) demonstrated significant antiparasitic activity against Leishmania major both in vitro and in vivo, including reductions in lesion size and parasite load in mice.

5. Additional Observations and Potential Applications
• Other research cited antiparasitic action of curcumin or its analogs against parasites such as Toxoplasma gondii, Plasmodium falciparum (malaria), Giardia lamblia, Cryptosporidium parvum, and Trypanosoma species.

• For example, P. falciparum appears sensitive to curcumin with impacts on histone acetylation, T. gondii may be inhibited via blocking glyoxalase activity, and Giardia motility may be affected through cytoskeletal disruption.

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