Historic Debate: Ben Franklin, Smallpox, and Early Vaccine Risks

Dr. McCullough traced how vaccine ideology began in 1721 Boston. Cotton Mather and Dr. Boylston promoted “variolation” — taking pus from one child with smallpox to infect another. At first mocked, even by Ben Franklin, the practice gained traction after Franklin’s own son died of smallpox.

From the very start, vaccines carried confusion, risk, and misplaced faith. Some children died immediately after variolation, yet leaders pressed on. What history reveals: medicine has too often advanced by experiment first, consequences later.

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Credit: The Henkel Conference – Ascension Lutheran Church

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