Shocking Study Shows BIG DEMENTIA RISK - COMMON MEDICATION

Shocking Study Shows BIG DEMENTIA RISK - COMMON MEDICATION

Sept. 25, 2025

SICKNESS PROFIT INDUSTRY - FOLLOW THE MONEY

Dr. Suneel Dhand

Primary Approved Uses (On-label)

1. Postherpetic Neuralgia (PHN): This is nerve pain that follows a shingles infection (herpes zoster). Gabapentin is effective in reducing the burning, shooting, or stabbing pain associated with this condition.

2. Partial-Onset Seizures: It is used as an add-on therapy (adjunctive treatment) for adults and children with epilepsy to control certain types of seizures. It is not usually a first-line treatment for seizures.

Common Off-Label Uses

This is where gabapentin is prescribed most frequently. "Off-label" means the use is not specifically approved by regulatory agencies like the FDA, but is supported by clinical experience and some scientific evidence.

1. Neuropathic Pain (Nerve Pain): This is one of its most widespread uses. It helps manage pain caused by damaged nerves, such as:

Diabetic Neuropathy: Burning or tingling pain in the feet and hands due to diabetes.

Peripheral Neuropathy: Nerve pain from other causes.

Central Pain: Pain after a stroke or spinal cord injury.

2. Restless Legs Syndrome (RLS): Gabapentin is often a first-line treatment for moderate to severe RLS, especially if it's daily or disruptive. It can be very effective in reducing the uncomfortable sensations and the urge to move the legs.

3. Anxiety: Particularly in certain settings like pre-operative anxiety or as an alternative for generalized anxiety disorder when first-line treatments are not suitable. (Note: It is not FDA-approved for this).

4. Other Chronic Pain Conditions: It is sometimes used for conditions like fibromyalgia and migraine prevention, although other medications are often preferred first.

Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain.

Methods: We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024. Adults diagnosed with chronic low back pain were included; those with prior gabapentin use, dementia, epilepsy, stroke, or cancer were excluded. Propensity score matching controlled for demographics, comorbidities, and pain medications. Patients were stratified by age and gabapentin prescription frequency. Primary outcomes were dementia and mild cognitive impairment.

Study: https://rapm.bmj.com/content/early/2025/07/02/rapm-2025-106577

Website: https://www.suneeldhand.com

Original: https://youtu.be/DntefqZLU6Y

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