NAD+ Reverses Alzheimer's Deficits: New Study Explains How Ep. 1268 NOV 2025

Alzheimer's disease (AD) is linked to aging and errors in how our genes are processed, a mechanism known as dysfunctional alternative RNA splicing (ASEs). The metabolite NAD+ is known to slow AD progression in preclinical studies.
This 2025 study in Science Advances provides a new mechanism . Researchers found that NAD+ augmentation corrects these harmful splicing errors. It appears to do this by regulating a key protein called EVA1C, which the study found is reduced in the hippocampus of human AD patients compared to cognitively normal ones.
Using mouse models with AD-like tau pathology , supplementing with NAD+ precursors (like NR or NMN) improved memory . Critically, when the researchers blocked the EVA1C protein (via adeno-associated virus-based knockdown) in the mice's hippocampus, the memory improvements from NAD+ were lost .
This suggests the NAD+-EVA1C splicing axis is a critical pathway for how NAD+ protects the brain, offering a potential new target for future AD therapies.
3. Disclaimers
• This information is for educational purposes only and should not be interpreted as medical advice.
• The study discussed was conducted on human cells , C. elegans (worms) , and mouse models . Further research is needed to confirm these specific mechanisms in humans.
• Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.
Ai R, Mao L, Jin X, et al. NAD+ reverses Alzheimer's neurological deficits via regulating differential alternative RNA splicing of EVA1C. Sci Adv. 2025;11(eady9811).
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