Remnants of a vampire clan that wanted to rule the world alone, but got defeated in a war by joined forces of other vampires and humans, kidnap the brother of a vampire war veteran. He looks for them in a secret vampire city. Jiro Mochizuki, a powerful "Old Blood" vampire and war hero known as the Silver Blade, who travels to a secret human-vampire city called the Special Zone with his younger brother, Kotaro, only to find the fragile peace threatened by resurfacing remnants of the Kowloon Bloodline—a dangerous type of vampire that turns victims into monstrous Kowloon Children—leading Jiro to fight to protect Kotaro and the Zone from this new threat.

Cadis Etrama Di Raizel (Rai), a powerful, ancient vampire known as the Noblesse, who awakens from an 820-year slumber to a modern world and tries to live peacefully as a high school student, only to find his new human friends and world threatened by a secret organization called the Union, forcing him to use his immense power to protect them. The story follows his efforts to adapt to modern life with his loyal servant, Frankenstein, while battling superhumans and uncovering secrets about his past and the Nobles.

Saya, a 400-year-old half-human, half-vampire warrior who hunts monstrous vampires called Chiropterans, working with a secret agency during the Vietnam War era in 1966 Japan, where she infiltrates a U.S. military high school to find hidden vampires, relying on her katana skills and confronting her own vampiric nature while seeking revenge against Onigen, the matriarch of the Chiropterans, who killed her father

The dhampir hunter D as he's hired by a wealthy family to rescue their daughter, Charlotte Elbourne, from the vampire nobleman Meier Link, only to find Charlotte went willingly, leading to a deadly race against rival hunters (the Marcus Brothers) and other supernatural threats as D confronts the truth of their forbidden romance and the ancient vampire plotting against them. The story centers on D's relentless pursuit, the clash with other hunters, and the ultimate revelation that Charlotte and Meier sought freedom from their world, culminating in a visually stunning battle and a journey to a vampire refuge in space.