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New Serotonergics with High Intracellular Bioavailability as Potentially Neuroplastic and Geroprotective Agents

New Serotonergics with High Intracellular Bioavailability as Potentially Neuroplastic and Geroprotective Agents
Yaroslav G. Zaitsev ORCID: 0000-0002-0069-2997 https://doi.org/10.5281/zenodo.18216431
January 2026 · Scientific Preprint
Data Availability & Methodology: Targets: 5-HT1A, 2A/B; MAPK/NF-κB; Neurogenics. In Silico: SAR Library (80+ scaffolds); pKi; ADME/Tox. Status: Preprint (2026). License: CC BY 4.0. Contact: [email protected]. Author: Ya. G. Zaitsev.

Erinacine A, hericenones, Hericium erinaceus, neurotrophic agents, rational drug design, non-psychedelic neuroplasticity, slow neuroplasticity, lipophilic 5-HT1A mimetics, NGF/BDNF induction, telomerase modulation, geroprotectors, MAPK/NF-κB signaling, in silico screening, SAR library.