ComfyUI on Fedora 43: System Python 3.14 and ROCm 6.4 Guide

In this screencast, we dive into a professional AI workstation setup on Fedora 43. I explain why I chose to install Python 3.14 packages system site-wide for ComfyUI instead of using virtual environments. We address the challenge of using the AMD Instinct Mi60 with ROCm 6.4, which no longer officially supports this GPU. You will see how this setup avoids package duplication and simplifies ROCm integration. We also run real-world tests using Z-Image-Turbo and Wan 2.1 1.3 Fun Inpaint to demonstrate stability and speed. Finally, we discuss the current status of onnxruntime-rocm and its expected release from Microsoft.

Related Blog Article: https://www.ojambo.com/amd-instinct-mi60-gpu-rocm-6-3-vs-6-4-running-comfyui-for-z-image-turbo

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