New Serotonergics with High Intracellular Bioavailability as Neuroplastic and Geroprotective Agents

New Serotonergics with High Intracellular Bioavailability as Potentially Neuroplastic and Geroprotective Agents

New Serotonergics with High Intracellular Bioavailability as Potentially Neuroplastic and Geroprotective Agents
Yaroslav G. Zaitsev ORCID: 0000-0002-0069-2997 https://doi.org/10.5281/zenodo.18216431
January 2026 · Scientific Preprint
Data Availability & Methodology: Targets: 5-HT1A, 2A/B; MAPK/NF-κB; Neurogenics. In Silico: SAR Library (80+ scaffolds); pKi; ADME/Tox. Status: Preprint (2026). License: CC BY 4.0. Contact: [email protected]. Author: Ya. G. Zaitsev.

Erinacine A, hericenones, Hericium erinaceus, neurotrophic agents, rational drug design, non-psychedelic neuroplasticity, slow neuroplasticity, lipophilic 5-HT1A mimetics, NGF/BDNF induction, telomerase modulation, geroprotectors, MAPK/NF-κB signaling, in silico screening, SAR library.