This Rare Encephalitis Case May Explain a Much Larger Post-COVID Brain Problem

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A rare case of autoimmune limbic encephalitis appears shortly after COVID-19. On the surface, it looks isolated. Immunologically, it raises a much bigger question.

This case involves anti-LGI1 encephalitis, driven by IgG4 antibodies—tolerance antibodies that disrupt synaptic function rather than cause inflammation. The result is memory loss, seizures, and cognitive failure, often with normal MRI and CSF.

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Before COVID, IgG4 diseases were linked to chronic antigen exposure—not viral illness. If this same biology is occurring at lower intensity across the population, it would not look like an encephalitis epidemic. It would look like widespread post-COVID “brain fog,” cognitive slowing, and emotional dysregulation—largely dismissed as stress.

In this video, I explain why this case may be a signal, not an anomaly, and what it could mean for post-COVID brain health.

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