Antibody Dependent Enhancement (ADE) & Covid-19 Variants

ADE is a phenomenon observed in animals during vaccine development against the coronaviruses and measles, respiratory syncytial virus, and dengue viruses previously.

In ADE, the inoculated animals develop the antibodies, but with time, the neutralizing antibodies decrease. When the animals were exposed to a wild-type coronavirus (to test vaccine effectiveness), instead of being protected the animals developed severe infections and died.

https://drjessesantiano.com/what-is-antibody-dependent-enhancement-and-why-should-you-care/