3 years ago

Omicron BA.2 Variant

BA.2 sub-lineage is in the news because of its increasing frequency compared to BA.1. Let's review the following questions:
What is it?
What are the mutations?
Is it more transmissible?
Is it more lethal?
Will it provide cross-reactivity?

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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

URL list from Saturday, Jan. 22 2022

DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/

SARS-CoV-2 Omicron variant - Wikipedia
https://en.wikipedia.org/wiki/SARS-CoV-2_Omicron_variant

Scientists find ‘stealth’ version of Omicron that may be harder to track | Coronavirus | The Guardian
https://www.theguardian.com/world/2021/dec/07/scientists-find-stealth-version-of-omicron-not-identifiable-with-pcr-test-covid-variant

Denmark to shut down public venues as virus infections rise | AP News
https://apnews.com/article/coronavirus-pandemic-lifestyle-health-travel-art-galleries-58f88e5635dc80fa56ad3a95343d904c

Denmark: Coronavirus Pandemic Country Profile - Our World in Data
https://ourworldindata.org/coronavirus/country/denmark

Sequence of traveller from South Africa failed to get assigned to any lineage by pangolin, with a long branch to Omicron · Issue #359 · cov-lineages/pango-designation
https://github.com/cov-lineages/pango-designation/issues/359

Proposal to split B.1.1.529 to incorporate a newly characterised sibling lineage · Issue #361 · cov-lineages/pango-designation
https://github.com/cov-lineages/pango-designation/issues/361

Thread by @PeacockFlu on Thread Reader App – Thread Reader App
https://threadreaderapp.com/thread/1483768659420094464.html

(17) shay fleishon on Twitter: "I took the defining mutations of BA.1 & BA.2 (NS only), and compared the resemblance between the 2 variants in main parts of the genome. Some difference in S1. E is the same, N & M are different in 1 mutation between the two variants. And...quite a difference when we go to ORF1ab https://t.co/xjl1IRvhmM" / Twitter
https://twitter.com/shay_fleishon/status/1480934070012059649?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1480934070012059649%7Ctwgr%5E%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fthreadreaderapp.com%2Fthread%2F1483768659420094464.html

(18) Bloom Lab on Twitter: "Here are site-wise plots generated from https://t.co/dr4oGVHUrS that explain why. BA.2 less antigenic escape than BA.1 because it lacks G446S. BA.1 + R346K is more escape because site 346 is major antigenic site. (7/n) https://t.co/bm8ZEN0Ty2" / Twitter
https://twitter.com/jbloom_lab/status/1470442877494824961?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1470442877494824961%7Ctwgr%5E%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fthreadreaderapp.com%2Fthread%2F1483768659420094464.html

(25) Mike Honey 💉💉💉 on Twitter: "@PeacockFlu Thanks for such a thorough explainer. Here’s the latest frequency picture for BA.2 https://t.co/3ADwoOPrh4" / Twitter
https://twitter.com/mike_honey_/status/1484855167275376645?s=21

Overview | Sites in SARS-CoV-2 RBD where mutations escape antibody binding
https://jbloomlab.github.io/SARS2_RBD_Ab_escape_maps/escape-calc/

(25) Chise 🧬🧫🦠💉 on Twitter: "Guys, BA.2 isn’t new. It’s been around since last year. It’s a sub-lineage to BA.1. They’re both still Omicron. It isn’t expected to be any more severe or expected to cause another wave. It might just eventually replace BA.1. End of the day, still Omicron. Let’s not lose focus." / Twitter
https://twitter.com/sailorrooscout/status/1484507422513319941?s=21

GISAID - hCov19 Variants
https://www.gisaid.org/hcov19-variants/

Nextstrain / ncov / gisaid / global
https://nextstrain.org/ncov/gisaid/global?tl=country

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