Paxlovid - How Does It Work?

Paxlovid - How Does It Work?

Pfizer's Paxlovid is made of two products. Ritonavir and PF-07321332 are two components of this drug. PF-07321332 is a protease for viral 3CL-Pro. While Ritonavir helps reduce the metabolism of the proteases to increase the life of this drug.

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URL list from Wednesday, Jan. 5 2022

Paxlovid: what we know about Pfizer’s Covid-19 pill
https://www.pharmaceutical-technology.com/features/paxlovid-pfizer-covid-19-pill/

Pfizer’s Novel COVID-19 Oral Antiviral Treatment Candidate Reduced Risk of Hospitalization or Death by 89% in Interim Analysis of Phase 2/3 EPIC-HR Study | Pfizer
https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

Ritonavir - Wikipedia
https://en.wikipedia.org/wiki/Ritonavir

Nirmatrelvir - Wikipedia
https://en.wikipedia.org/wiki/Nirmatrelvir

3C-like protease - Wikipedia
https://en.wikipedia.org/wiki/3C-like_protease

Mechanisms of SARS-CoV-2 Transmission and Pathogenesis: Trends in Immunology
https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30233-7

Antivirals for COVID-19: five questions that must be answered - The Pharmaceutical Journal
https://pharmaceutical-journal.com/article/feature/antivirals-for-covid-19-five-questions-that-must-be-answered

Antivirals for COVID-19_ A critical review
https://cegh.net/article/S2213-3984(20)30176-7/pdf

Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S2211124721004721

(PDF) Repurposed Drugs, Molecular Vaccines, Immune-Modulators, and Nanotherapeutics to Treat and Prevent COVID-19 Associated with SARS-CoV-2, a Deadly Nanovector
https://www.researchgate.net/publication/344897437_Repurposed_Drugs_Molecular_Vaccines_Immune-Modulators_and_Nanotherapeutics_to_Treat_and_Prevent_COVID-19_Associated_with_SARS-CoV-2_a_Deadly_Nanovector#pf6

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