Self amplifying mRNA jabs: Lower dose, higher uncertainty, variability and risk | Kati Schepis

The Pfizer and Moderna COVID genetic jabs work on the basis of messenger RNA (mRNA) which is very comparable to a recipe. The mRNA is transported into the cell (comparable to a restaurant) using the surrounding lipid nanoparticles (LNP) to protect it en route and allow it entry. (One problem with the lipid nanoparticles is that they are non-specific: they can go inside any cell, including cells where you don't want it to have entry.)

Once inside the cell, the mRNA is extracted from the lipid nanoparticles. The cell then starts producing spike proteins in accordance with the mRNA recipe, similar to a McDonald's restaurant producing Big Macs in according with the Big Mac recipe.

mRNA comes in 3 possible forms:

1. The 'standard' form which is not used in any of the current gene therapies
2. The stabilized form, which is used in almost all of the current Pfizer and Moderna injections
3. The self-amplifying form

The stabilized form of the mRNA has the 'advantage' of being more resistant to degradation. That way the cell may continue producing more spike proteins for a longer duration. However, it remains to be seen if this is an advantage, because:

1. The spike protein is a toxin
2. There can be a huge variability in production: some people may produce almost no spike proteins while others may produce an absurd amount. The former group may receive an 'underdose' (assuming there can be an underdose for an ineffective toxin) while the latter group may receive a severe overdose.
3. It's unknown which person will produce how much spike protein.

It seems that the production of spike protein will continue until either the mRNA has degraded or the cell is destroyed.

With the self-amplifying form of mRNA, the recipe, once inside the cell, can start to copy itself. The advantage of this is that a lower dose is needed to get the same final amount of mRNA. A lower dose should mean less direct side-effects.

However, this amplifies the above mentioned unknowns and risks. How do you know when the copying stops? How do you know if it will not go on forever (in some people)?

Kati SCHEPIS completed her pharmacy studies at the ETH in Zurich in 2003 and worked in the Swiss branch of a global pharmaceutical company for over 12 years, first in drug approval and then in the medical department. She lives in Winterthur and is the proud mother of two boys.

SOURCE: https://rumble.com/vvfu43-variations-of-mrna-technology-boosters-and-self-amplifying-mrna-vaccines.html