Episode 12.1/13: Cell Construction & Assembly Problem // A Course on Abiogenesis by Dr. James

Touted as his best episode yet, Dr. James Tour brings everything taught previously into Part 1 of this multipart episode, discussing the construction of the cell and the problems of its assembly. With the surgical lights now shining directly on the subject, Dr. Tour begins his vivisection, exposing the sophistry of the origin-of-life narrative held by many while systematically excising fallacy by fallacy where the storytelling should stop. With the state of the origin-of-life field remaining stagnant post-Miller-Urey, Dr. Tour short circuits with yet another reference—an honest scientist studying the homochirality problem who remains circumspect in conducting autocatalysis toward homochirality with prebiotic relevance. Finally, after the biopsies of dissected specimens like RNA World come back from the pathology lab showing no signs of viability, Dr. Tour lists requirements not addressed by the cited fairy tale, including an unraveling of covalent molecular synthesis that somehow is being hand-waved into existence via a magical, nonsensical force called "spontaneous assembly".

As promised, video on Information Origins:
https://youtu.be/YAVHYhiVbyY
(Guest: Dr. Bill Dembski)

Video Index:
00:00 - Introduction
00:37 - Reasons & Intent of this Abiogenesis Series
03:27 - Miller-Urey Problem & Beyond
10:18 - Flashback: Misunderstanding of Cited Video's Cited Literature
14:26 - Stop No. 1: No Small Misinterpretation
15:00 - Homochirality Advance Still Falls Short, say Authoring Scientists
22:57 - "No Problem" Nucleotides
28:00 - Stop No. 2: Researcher Hype to Layperson Mislead
29:14 - Panspermia: Kick the can to space
30:16 - Code Word: "Spontanous"
31:27 - Sleight of hand: Monomeric sugars
31:48 - Stop No. 3: No Sugars
32:59 - The Polymerization Problem & "some mechanism"
35:43 - Stop No. 4: Skipping Ribose
36:11 - Prebiotic Earth: RNA, "Hot" &"Clay"
44:43 - RNA's "UH-OH", impurity shutdown, & no interference?
49:46 - Stop No. 4: Information & RNA Failures
50:47 - Ribozyme vs Prebiotic Relevance
53:14 - Water break
55:04 - RNA World Problems, Krishnamurthy & more
58:36 - Condensation Reactions in Water
1:01:09 - Stop No 5: In practice, ineffective
1:01:25 - Enantiomeric Amino Acids & Polymerization, Not Shown
1:04:34 - Stop No. 6: Too much not shown
1:06:07 - Fatty acids, not spontaneously
1:08:39 - Stop No. 7: Fatty Acid Failure
1:08:54 - Self-Assembly: "Imagine" the "Hypothetical"
1:10:10 - Hypercycle Magic
1:11:01 - Stop No. 8: No Metabolism in Protocells
1:13:13 - What's Next

Clarification at 35:58: It was stated "If it's not homochiral, it's not ribose", meaning, if it's not D-ribose, then it's not of general prebiotic relevance, which is what was assumed from the discussion context.

Series Links | Addressing Abiogenesis & Common Misconceptions
======
Series Trailer: https://youtu.be/N-RvMStTkx4
------
0 - Reasons for this Series: https://youtu.be/71dqAFUb-v0
1 - Introduction to Abiogenesis: https://youtu.be/NqoVxwdWWpg
2 - Primordial Soup: https://youtu.be/tNbl-g8QoAg
3 - Hype: https://youtu.be/Q6b76XQQN00
4 - Homochirality: https://youtu.be/tqbpd3CmBgE
5 - Carbohydrates: https://youtu.be/rdqd_EvpsZM
6 - Building Blocks of Building Blocks: https://youtu.be/rdqd_EvpsZM
7 - Peptides: https://youtu.be/0Hv6KjB0j8Y
8 - Nucleotides: https://youtu.be/CYiguQYCSio
9 - Intermediate Summary & a Call to Colleagues: https://youtu.be/ImPxfmKrmoY
10 - Lipids: https://youtu.be/QTQd5Ifqv2g
11 - Chiral-induced Spin Selectivity: https://youtu.be/VKEZSfuMgL0
12.1 - Cell Construction & The Assembly Problem, Part 1: https://youtu.be/IaJo5jWs_6k
12.2 - Cell Construction & The Assembly Problem, Part 2: https://youtu.be/fDayvhch_W4
13 - Summary & Projections: https://youtu.be/71GTCHkId6M

Donna Blackmond–"Autocatalytic Models for Symmetry Breaking and the Emergence of Homochirality": https://youtu.be/tGTVZ78JLi8

DNA animations by wehi.edu.au:
https://youtu.be/7Hk9jct2ozY​
Transcription - Central Dogma Part 1 by wehi.edu.au:
https://youtu.be/DA2t5N72mgw​
Translation - Central Dogma Part 2 by wehi.edu.au:
https://youtu.be/WkI_Vbwn14g

Water break: "The Elevator Bossa Nova" by bensound.com
https://www.bensound.com/royalty-free...

Link to cited video ("Elucidating the Agenda of James Tour: A Defense of Abiogenesis") is in video description of Episode 0 - "Reasons" here: https://youtu.be/71dqAFUb-v0

Video thumbnail uses still frame image taken in Flash Graphene video in phrase "any carbon source" at 0:12: https://youtu.be/hhN5I_ocLSU

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God bless you.

#Abiogenesis #JamesTour #OriginOfLife

~
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