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Understanding the science of marijuana began in the mid-1960s with the identification of THC (delta-9-tetrahydrocannabinol) as marijuana’s main active ingredient. Twenty years later, scientists identified the sites in the brain and body where marijuana acts and called them cannabinoid (CB) receptors.
Scientists then discovered the body’s own natural chemicals—anandamide and 2-AG (2-arachidonoyl glycerol)—which also act on CB receptors. These chemicals (called cannabinoids), along with their receptors, make up the endocannabinoid (EC) system.
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