colon cancer and mRNA

Colon cancer

Breast, prostate, lung, bowel, melanoma, kidney, lymphoma

Cause of cancer deaths, lung bowel

US data, 10.5% of newly diagnosed colorectal cancers now occur in people younger than 50

Expected to rise to 15% by 2030

https://www.cancer.org/cancer/types/colon-rectal-cancer/causes-risks-prevention/risk-factors.html

Colorectal cancer is rising among people who are younger than age 50, and the reason for this remains unclear.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9177054/

Index of suspicion at younger age

Anaemia, (red flag), SOBE, fatigue, pallor

Abdominal pain, bloating

Diarrhoea or constipation

Change in normal bowel habit, (looser, more or less often), 3 weeks

PR bleed, mixed, streaked, dark and tarry

Pencil stools

Feeling of fullness after passing stool

Straining

Abdo or back passage pain

Lumps or obstruction

Weight loss

DVT
Aetiology

Obesity

Physical activity

DM2

Diet

Microbiome, probiotics, prebiotics

Vitamin D

Smoking

Alcohol

Microplastics

Personal and family history

Adenomatous polyps

Inflammatory bowel disease

Lynch syndrome, hereditary non-polyposis colon cancer or (HNPCC)

mRNA injections

Rates of Colorectal and Other Cancers Are Rising in Young Adults, Puzzling Researchers

https://jamanetwork.com/journals/jama/fullarticle/2834865?guestAccessKey=4f8a586a-606a-42e6-87af-bf379c315f4b&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=olf-tfl_&utm_term=053025

Incidence of 14 cancer types increased among people younger than 50 years.

9 of those cancer types, including colorectal cancer and breast cancer, also increased in some over 50s.

Factors

Increased imaging

But, many early-onset colorectal tumors diagnosed after symptoms

Hyuna Sung, cancer surveillance research, American Cancer Society

“Given that similar trends have been observed in the US and many other countries, it’s crucial for researchers to address how much of this is driven by shifts in risk factors versus changes in diagnostic practices,”
2024 report

https://www.nboca.org.uk/wp-content/uploads/2024/02/NBOCA-SotN.pdf
38,604 patients
New diagnosis

2021 to 2022 = 35,779

2022 to 2023 = 38,604
By October 2020, monthly diagnoses had returned to pre-pandemic levels,

from April 2021 the number of monthly diagnoses continued to rise.

The total number of patients diagnosed with colorectal cancer during 2021/22 surpassed annual figures prior to the COVID-19 pandemic.
2025 Report

https://rcs-ceu.shinyapps.io/NBOCA/

https://www.nboca.org.uk/wp-content/uploads/2025/01/NBOCA-SotN-Patient-Report-2024_v1.0_09.01.25.pdf
The potential for mRNA vaccines to cause cancer

Theoretical mechanisms

DNA Integration

mRNA or fragments, reverse transcriptase, potentially disrupting tumour suppressor genes or activating oncogenes

DNA contamination, integrate into the genome

Contaminants in Vaccine Production

Pfizer COVID-19 modRNA vaccines also contained an SV40

Inactivated tumour suppressor genes, p53 and Rb, promoting unchecked cell growth

Prolonged Spike Protein Expression

N1-methyl-pseudouridine-modified mRNA encoding the SARS-COVID-19 Spike protein

Lipid nanoparticle (LNP) delivery to stem cells

Sustained spike protein production,

induce chronic inflammation,

disrupt cellular repair mechanisms.

Immune Suppression or Dysregulation

Molecular Mimicry, Autoimmunity, inflammation

Alter regulatory T-cell function, (potentially allowing pre-existing cancers to progress).

(If the spike protein shares epitopes with tumour suppressor proteins)